The Gene Ontology Annotation (GOA) Project—Application of GO in SWISS-PROT, TrEMBL and InterPro

As proteomics research gains momentum, biologists need new ways to access and analyse information on proteins. Many new gene products, from a wide range of species, are being added to the SWISS-PROT Protein Knowledgebase — the world’s most highly annotated protein sequence database — and its supplement, TrEMBL [3]. To fully exploit the potential of these data, the SWISSPROT group at EBI aims to capture all the available biological information related to these sequences and especially components of the human proteome. One important challenge in this endeavour is to make all our databases describe, in a consistent way, what each protein does.